EPI is characterized by deficiencies in the amount or activity of exocrine pancreatic enzymes. This can result in the inability to digest food properly, or maidigestion.2,4-6
In addition to the treatment of causative factors, there are 2 key goals for managing EPI.5,7-10
Improving digestion and absorption of nutrients
Relieving GI signs and symptoms of EPI
Managing EPI includes...5,7-10
Lifestyle and dietary modifications
Vitamin and nutrient supplementation
Pancreatic enzyme therapy
ZENPEP® (pancrelipase) is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions.
1. ZENPEP [package insert]. Irvine, CA: Allergan USA, Inc.; March 2017. 2. Wooldridge JL, Heubi JE, Amaro-Galvez R, et al. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009;8:405-417. 3. Bruno MJ, Haverkort EB, Tytgat GNJ, van Leeuwen DJ. Maldigestion associated with exocrine pancreatic insufficiency: implications of gastrointestinal physiology and properties of enzyme preparations for a cause-related and patient-tailored treatment. Am J Gastroenterol. 1995;90:1383-1393. 4. Al-Kaade S. Exocrine pancreatic insufficiency. Medscape website. http://emedicine.medscape.com/article/2121028- overview. Accessed March 16, 2017. 5. Hardt PD, Ewald N. Exocrine pancreatic insufficiency in diabetes mellitus: a complication of diabetic neuropathy or a different type of diabetes? Exp Diabetes Res. 2011;2011:1-7. 6. Domínguez-Muñoz JE. Pancreatic exocrine insufficiency: diagnosis and treatment. J Gastroenterol Hepatol. 2011;26(suppl 2):12-16. 7. Domínguez-Muñoz JE. Chronic pancreatitis and persistent steatorrhea: what is the correct dose of enzymes? Clin Gastroenterol Hepatol. 2011;9:541-546. 8. Sikkens ECM, Cahen DL, Kuipers EJ, Bruno MJ. Pancreatic enzyme replacement therapy in chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24:337-347.