Flexible dosing may allow patients to minimize the number of capsules needed or get close to the calculated dose
May allow for customized dosing
May reduce the number of capsules needed
Gets your patient close to the calculated dose
Each ZENPEP capsule strength contains the specified amount of lipase, protease, and amylase1
ZENPEP combined insurance coverage through commercial and Medicare Part D is 94%, with unrestricted access. Coverage is the same for all dosage strengths2
Data are not guarantee of coverage, or partial or full payment, by any payers listed. Actual benefits determined by respective plan adminstrator. Insurer plans, coverage criteria, and formularies are subject to change without notice. Check each patient's coverage with applicable insurer. Allergan does not endorse any individual plans. Formulary coverage does not imply efficacy or safety.
Use the app below to calculate the per-meal ZENPEP dose for your patients with EPI due to cystic fibrosis or other conditions.
ZENPEP is not interchangeable with any other pancrelipase product. Therapy should be initiated at the lowest recommended dose and gradually increased. The dosage of ZENPEP should be individualized based on clinical symptoms, the degree of steatorrhea present, and the fat content of the diet. Dosing should not exceed the recommended maximum dosage set forth by the Cystic Fibrosis Foundation Consensus Conferences Guidelines.
per 120 mL of formula or per breastfeeding
†It is recommended, unless clinically indicated, that enzyme doses should be less than 2,500 lipase units/kg of body weight per meal (or less than 10,000 lipase units/kg of body weight per day) or less than 4,000 lipase units/g of fat ingested per day.
Doses greater than 2,500 lipase units/kg of body weight per meal (or greater than 10,000 lipase units/kg of body weight per day) should be used with caution and only if they are documented to be effective by 3-day fecal fat measures that indicate a significantly improved coefficient of fat absorption. Patients receiving higher doses than 6,000 lipase units/kg of body weight per meal should be examined and the dosage either immediately decreased or titrated downward to a lower range.
DISCLAIMER: By using this dosing calculator, you agree to the following: The dosing calculator is being provided "AS IS" and is intended for healthcare professional (HCP) use only. The dosing calculator is to be used only in conjunction with ZENPEP® (pancrelipase) delayed-release capsules. All calculations should be confirmed before use. The information being provided is not a substitute for clinical judgement. While the tool attempts to be as accurate as possible, it should not be relied upon as being comprehensive and error-free. Allergan, nor any party involved in the publication of this site, shall be liable to you or others for any decisions made or actions taken by you or others in reliance of this information. The user assumes all responsibility and risk for the use of this tool.
If you are not an HCP and have questions about ZENPEP dosing, please contact your HCP.
For complete information on dosage and administration, please see full Prescribing Information.
ZENPEP® (pancrelipase) is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions.
1. ZENPEP [package insert]. Irvine, CA: Allergan USA, Inc.; March 2017. 2. Data on file. Allergan Pharmaceuticals.