For the treatment of EPI due to CF or other conditions ZENPEP helps fuel nutritional health, increasing coefficient of fat absorption (CFA) by 26 percentage points vs placebo1
ZENPEP demonstrated both non-inferiority and equivalence to Creon in dietary fat absorption (ZENPEP 84.1% vs Creon 85.3%; difference in LS means: –1.3% [95% CI, –3.6 to 1.1] P=0.297)
PPIs, H2 blockers, motility agents, buffering agents, laxatives, agents for gastric ulcers, and synthetic fat substitutes or fat-blocking nutritional supplements
ZENPEP® (pancrelipase) is a combination of porcine-derived lipases, proteases, and amylases indicated for the treatment of exocrine pancreatic insufficiency due to cystic fibrosis, or other conditions.
1. ZENPEP [package insert]. Irvine, CA: Allergan USA, Inc.; March 2017. 2. Wooldridge JL, Heubi JE, Amaro-Galvez R, et al. EUR-1008 pancreatic enzyme replacement is safe and effective in patients with cystic fibrosis and pancreatic insufficiency. J Cyst Fibros. 2009;8(6):405-417. 3. Taylor CJ, Thieroff-Ekerdt R, Shiff S, Magnus L, Fleming R, Gommoll C. Comparison of two pancreatic enzyme products for exocrine insufficiency in patients with cystic fibrosis. J Cyst Fibros. 2016;15(5):675-680. 4. Data on file. Aptalis Pharma US, Inc.